Principles of the prolactin/vasoinhibin axis
نویسندگان
چکیده
The hormonal family of vasoinhibins, which derive from the anterior pituitary hormone prolactin, are known for their inhibiting effects on blood vessel growth, vasopermeability, and vasodilation. As pleiotropic hormones, vasoinhibins act in multiple target organs and tissues. The generation, secretion, and regulation of vasoinhibins are embedded into the organizational principle of an axis, which integrates the hypothalamus, the pituitary, and the target tissue microenvironment. This axis is designated as the prolactin/vasoinhibin axis. Disturbances of the prolactin/vasoinhibin axis are associated with the pathogenesis of retinal and cardiac diseases and with diseases occurring during pregnancy. New phylogenetical, physiological, and clinical implications are discussed.
منابع مشابه
From Bench to Bedside: Translating the Prolactin/Vasoinhibin Axis
The prolactin/vasoinhibin axis defines an endocrine system, in which prolactin (PRL) and vasoinhibins regulate blood vessel growth and function, the secretion of other hormones, inflammatory and immune processes, coagulation, and behavior. The core element of the PRL/vasoinhibin axis is the generation of vasoinhibins, which consists in the proteolytic cleavage of their precursor molecule PRL. V...
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Prolactin and growth hormone are produced in the anterior pituitary gland and secreted into the circulation to execute their diverse physiological effects. They are also produced at various extrapituitary sites. Apart from the traditional, well-known effects mediated by the full-length hormones, they serve as the source for vasoinhibins, which are generated by proteolytic cleavage of prolactin ...
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